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Sugi Predict / Compounds / SCHEMBL1967178

SCHEMBL1967178

SCHEMBL1967178

CC(NC(=O)c1c(O)c2cc(Cl)cn2n(Cc2ccc(F)cc2)c1=O)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 5/20 0.42
▸ P2RX3 P56373 1/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ MAPK1 P28482 1/20 0.36
▸ KMT2A Q03164 3/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ ITGB1 P05556 1/20 0.36
▸ ITGA4 P13612 1/20 0.36
▸ ITGB7 P26010 1/20 0.36
▸ EGLN3 Q9H6Z9 2/20 0.35
▸ EGLN2 Q96KS0 1/20 0.35
▸ EGLN1 Q9GZT9 1/20 0.35
▸ KDM4C Q9H3R0 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ ERAP1 Q9NZ08 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ CNR1 P21554 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1967179 1.00 CNR2 (0.42) CNR2P2RX3L3MBTL1MAPK1KMT2A
SCHEMBL1967836 0.93 P2RX3 (0.39) P2RX3KMT2AMEN1EGLN3EGLN2
SCHEMBL1967838 0.93 P2RX3 (0.39) P2RX3KMT2AMEN1EGLN3EGLN2
SCHEMBL1966123 0.93 EGLN1 (0.44) CNR2EGLN3EGLN2EGLN1HIF1A
SCHEMBL1966122 0.93 EGLN1 (0.44) CNR2EGLN3EGLN2EGLN1HIF1A
SCHEMBL1968648 0.90 EGLN1 (0.47) P2RX3EGLN3EGLN2EGLN1ALDH1A1
SCHEMBL1968650 0.90 EGLN1 (0.47) P2RX3EGLN3EGLN2EGLN1ALDH1A1
SCHEMBL1968474 0.90 EGLN1 (0.42) ITGB1ITGA4ITGB7EGLN1ALDH1A1
SCHEMBL1968476 0.90 EGLN1 (0.42) ITGB1ITGA4ITGB7EGLN1ALDH1A1
SCHEMBL1971151 0.90 EGLN1 (0.42) ITGB1ITGA4ITGB7EGLN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2334682-B1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS FIBROGEN INC (US) 2017-10-04 — — EP claimed
US-8217043-B2 Compounds and methods for their use FIBROGEN, INC. (US) 2012-07-10 — — US claimed
US-20100047367-A1 COMPOUNDS AND METHODS FOR THEIR USE FIBROGEN, INC. 2010-02-25 — — US claimed
EP-2334682-B1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS FIBROGEN INC (US) 2017-10-04 — — EP disclosed
US-8217043-B2 Compounds and methods for their use FIBROGEN, INC. (US) 2012-07-10 — — US disclosed
EP-2334682-A1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS Fibrogen, Inc. (US) 2011-06-22 — — EP disclosed
WO-2010022240-A1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS FIBROGEN, INC. (US) 2010-02-25 — — WO disclosed
US-20100047367-A1 COMPOUNDS AND METHODS FOR THEIR USE FIBROGEN, INC. 2010-02-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100047367-A1 COMPOUNDS AND METHODS FOR THEIR USE HIF1AN, HIF1A, EGLN3 CNR2 2280/4885P2RX3 3566/4885L3MBTL1 2445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.