Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.61 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | NT5E | P21589 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662799 | 0.85 | KDM1A (0.63) | KDM1AEGFRFGFR1KDRNPC1 | |
| SCHEMBL16976932 | 0.85 | EGFR (0.67) | KDM1AEGFRFGFR1KDRKCNK3 | |
| SCHEMBL6966254 | 0.84 | EGFR (0.70) | KDM1AEGFRFGFR1KDRNPC1 | |
| SCHEMBL24934054 | 0.83 | DHX9 (0.69) | EGFRFGFR1KDRKCNK3KCNK9 | |
| SCHEMBL21237224 | 0.83 | KDM1A (0.61) | KDM1AEGFRFGFR1KDRNPC1 | |
| SCHEMBL21237370 | 0.83 | EGFR (0.61) | KDM1AEGFRFGFR1KDRMAPK8 | |
| SCHEMBL28692735 | 0.79 | LMNA (0.63) | KDM1AEGFRFGFR1KDRKCNK3 | |
| SCHEMBL17003226 | 0.79 | KDM1A (1.00) | KDM1A | |
| SCHEMBL16482524 | 0.79 | KDM1A (1.00) | KDM1A | |
| SCHEMBL16675166 | 0.78 | KCNK3 (0.89) | KCNK3KCNK9KCNH2NT5ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |