Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25884344 | 0.89 | NOTUM (0.49) | NOTUMNPSR1ALOX15GBA1 | |
| SCHEMBL17369045 | 0.85 | GLS (0.45) | GBA1 | |
| SCHEMBL7963203 | 0.85 | NOTUM (0.49) | NOTUMNPSR1ALOX15 | |
| SCHEMBL24812463 | 0.84 | GBA1 (0.53) | NOTUMGBA1 | |
| SCHEMBL23011813 | 0.84 | GBA1 (0.41) | GBA1 | |
| SCHEMBL25882774 | 0.83 | NOTUM (0.47) | NOTUMNPSR1ALOX15GBA1 | |
| SCHEMBL24256389 | 0.83 | NOTUM (0.47) | NOTUMNPSR1ALOX15 | |
| SCHEMBL29324043 | 0.80 | NOTUM (0.45) | NOTUMNPSR1ALOX15GBA1 | |
| SCHEMBL23518630 | 0.80 | GBA1 (0.43) | NOTUMGBA1 | |
| SCHEMBL16579400 | 0.79 | NOTUM (0.52) | NOTUMNPSR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230346951-A1 | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS | YALE UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| US-20170340746-A1 | PEGYLATED CARFILZOMIB COMPOUNDS | AMGEN INC. | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340746-A1 | PEGYLATED CARFILZOMIB COMPOUNDS | MCL1, FCGRT, MAN2B1 | NOTUM 3532/4885NPSR1 1405/4885ALOX15 1615/4885 |
| US-20230346951-A1 | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS | ASGR1, MSR1, LDLR | NOTUM 2312/4885NPSR1 171/4885ALOX15 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.