Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 7/20 | 0.36 |
| ▸ | CDK8 | P49336 | 7/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878013 | 0.88 | CREBBP (0.47) | CREBBPBRD4CCNCCDK8AXL | |
| SCHEMBL19643965 | 0.88 | CREBBP (0.47) | CREBBPBRD4CCNCCDK8AXL | |
| SCHEMBL24368131 | 0.77 | CREBBP (0.44) | CREBBPBRD4 | |
| SCHEMBL19660413 | 0.75 | CREBBP (0.47) | CREBBPBRD4CCNCCDK8 | |
| SCHEMBL19663200 | 0.74 | CREBBP (0.47) | CREBBPBRD4 | |
| SCHEMBL21237550 | 0.74 | CREBBP (0.47) | CREBBPBRD4 | |
| SCHEMBL21237382 | 0.72 | CREBBP (0.45) | CREBBPBRD4 | |
| SCHEMBL21419225 | 0.72 | CREBBP (0.49) | CREBBPBRD4 | |
| SCHEMBL19643357 | 0.66 | CREBBP (0.42) | CREBBPBRD4MAPK1 | |
| SCHEMBL30878068 | 0.66 | CREBBP (0.42) | CREBBPBRD4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |