Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19644121 | 0.79 | ROCK2 (0.35) | — | |
| SCHEMBL19662554 | 0.79 | IRAK4 (0.47) | HRH3 | |
| SCHEMBL29487321 | 0.78 | HRH4 (0.44) | HRH4PDE5AHRH3PTGESKDM4E | |
| SCHEMBL23107674 | 0.72 | LRRK2 (0.41) | HRH4LRRK2FFAR4PTGESSLC40A1 | |
| SCHEMBL22872852 | 0.72 | KMT2A (0.49) | PDE5AKDM4ECDK7CDK9 | |
| SCHEMBL19662557 | 0.71 | IRAK4 (0.56) | — | |
| SCHEMBL38659897 | 0.71 | PRMT5 (0.37) | HRH4KDM4EL3MBTL1 | |
| SCHEMBL22411411 | 0.70 | KMT2A (0.47) | PDE5AKDM4ECDK7CDK9 | |
| SCHEMBL3024650 | 0.70 | JAK3 (0.42) | LRRK2PTGESJAK3CDK9 | |
| SCHEMBL30872619 | 0.70 | JAK3 (0.42) | LRRK2PTGESJAK3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205766-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | PHARMACYCLICS LLC (US) | 2017-11-30 | — | — | WO | disclosed |