Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19663154 | 0.79 | HRH4 (0.40) | — | |
| SCHEMBL19662574 | 0.75 | ROCK2 (0.41) | ROCK2 | |
| SCHEMBL19662554 | 0.70 | IRAK4 (0.47) | — | |
| SCHEMBL38659897 | 0.67 | PRMT5 (0.37) | — | |
| SCHEMBL19662575 | 0.66 | CACNB4 (0.44) | — | |
| SCHEMBL29907250 | 0.65 | LMNA (0.43) | — | |
| SCHEMBL1992034 | 0.65 | LMNA (0.43) | — | |
| SCHEMBL16466554 | 0.62 | PRMT5 (0.47) | — | |
| SCHEMBL11860802 | 0.62 | METAP2 (0.42) | — | |
| SCHEMBL16541493 | 0.62 | PRMT5 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205766-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | PHARMACYCLICS LLC (US) | 2017-11-30 | — | — | WO | disclosed |