Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ciprofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.90 |
| ▸ | LMNA | P02545 | 5/20 | 0.90 |
| ▸ | HPGD | P15428 | 4/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | TOP2A | P11388 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.90 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciprofloxacin SCHEMBL28985303 | 0.95 | KDM4E (0.96) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL4459712 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL29137332 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL2325956 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL345730 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL2900 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL42310 | 0.94 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL1230167 | 0.94 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL2465661 | 0.94 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL21519294 | 0.94 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4603146-A2 | COMBINATION OF ZIDOVUDINE AND FLUOROQUINOLONE ANTIBIOTIC | Helperby Therapeutics Limited (GB) | 2025-08-20 | — | — | EP | disclosed |
| EP-4028022-B1 | COMBINATION OF ZIDOVUDINE AND FLUOROQUINOLONE ANTIBIOTIC | HELPERBY THERAPEUTICS LTD (GB) | 2025-07-09 | — | — | EP | disclosed |
| US-20230233559-A1 | COMBINATION OF ZIDOVUDINE AND FLUOROQUINOLONE ANTIBIOTIC | HELPERBY THERAPEUTICS LIMITED (GB) | 2023-07-27 | — | — | US | disclosed |
| CN-114786681-A | Combinations of zidovudine and fluoroquinolone antibiotics | 赫尔普百治疗有限公司 | 2022-07-22 | — | — | CN | disclosed |
| EP-4028022-A1 | COMBINATION OF ZIDOVUDINE AND FLUOROQUINOLONE ANTIBIOTIC | Helperby Therapeutics Limited (GB) | 2022-07-20 | — | — | EP | disclosed |
| WO-2021048554-A1 | COMBINATION OF ZIDOVUDINE AND FLUOROQUINOLONE ANTIBIOTIC | HELPERBY THERAPEUTICS LIMITED (GB) | 2021-03-18 | — | — | WO | disclosed |
| EP-2938327-B1 | FOAMABLE OTIC PHARMACEUTICAL COMPOSITIONS | OTIC PHARMA LTD (IL) | 2017-12-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233559-A1 | COMBINATION OF ZIDOVUDINE AND FLUOROQUINOLONE ANTIBIOTIC | DUT, DPYD, IMPDH1 | KDM4E 1132/4885ALDH1A1 1761/4885LMNA 3524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.