Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19665596 | 0.84 | MAPK8 (0.46) | MAPK8SYKEGFRJAK3ITK | |
| SCHEMBL19665732 | 0.84 | USP30 (0.48) | BTKMAPK3 | |
| SCHEMBL29802534 | 0.84 | USP30 (0.48) | BTKMAPK3 | |
| SCHEMBL19665675 | 0.84 | HDAC3 (0.45) | MAPK8SYKEGFRBTKMAPK9 | |
| SCHEMBL19665706 | 0.83 | GSK3A (0.50) | MAPK8ULK1SYKEGFRJAK3 | |
| SCHEMBL3190443 | 0.82 | KMT2A (0.39) | JAK3BTKCCNKCDK12 | |
| SCHEMBL1694067 | 0.81 | JAK3 (0.44) | EGFRJAK3ITKBTKMAPK3 | |
| SCHEMBL19665733 | 0.80 | MAPK8 (0.47) | MAPK8SYKEGFRJAK3BTK | |
| SCHEMBL15973997 | 0.79 | EGFR (0.56) | SYKEGFRJAK3ITKBTK | |
| SCHEMBL19665692 | 0.78 | EPHX1 (0.50) | SYKBTKCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464287-B1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2022-06-08 | — | — | EP | disclosed |
| US-11344554-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2022-05-31 | — | — | US | disclosed |
| US-20200330469-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2020-10-22 | — | — | US | disclosed |
| US-10736899-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2020-08-11 | — | — | US | disclosed |
| US-10420771-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3464287-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | Celgene Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| US-20180280398-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2018-10-04 | — | — | US | disclosed |
| US-10016436-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2018-07-10 | — | — | US | disclosed |
| WO-2017210399-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORPORATION (US) | 2017-12-07 | — | — | WO | disclosed |
| US-20170348316-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORPORATION | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200330469-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, UMPS, PNP | MAPK8 3431/4885ULK1 1637/4885SYK 3528/4885 |
| US-20170348316-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, NUDT1, UMPS | MAPK8 3532/4885ULK1 1501/4885SYK 3762/4885 |
| US-10420771-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | MAPK8 3423/4885ULK1 1732/4885SYK 3535/4885 |
| US-10736899-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | MAPK8 3431/4885ULK1 1637/4885SYK 3528/4885 |
| US-10016436-B2 | Animal and human anti-malarial agents | HPRT1, NUDT1, UMPS | MAPK8 3532/4885ULK1 1501/4885SYK 3762/4885 |
| US-11344554-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | MAPK8 3431/4885ULK1 1637/4885SYK 3528/4885 |
| US-20180280398-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, UMPS, PNP | MAPK8 3431/4885ULK1 1637/4885SYK 3528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.