Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.69 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.69 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966678 | 0.94 | S1PR1 (0.77) | S1PR1S1PR3S1PR4S1PR5LMNA | |
| SCHEMBL1964841 | 0.92 | S1PR1 (0.81) | S1PR1S1PR3S1PR4S1PR5LMNA | |
| SCHEMBL1966424 | 0.88 | S1PR1 (0.80) | S1PR1S1PR3S1PR4S1PR5LMNA | |
| SCHEMBL1965049 | 0.88 | S1PR1 (0.73) | S1PR1S1PR3S1PR4S1PR5LMNA | |
| SCHEMBL1969050 | 0.87 | S1PR1 (0.72) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL28795169 | 0.85 | S1PR1 (0.69) | S1PR1S1PR3S1PR4S1PR5LMNA | |
| SCHEMBL1647943 | 0.84 | S1PR1 (0.70) | S1PR1S1PR3S1PR4S1PR5LMNA | |
| SCHEMBL1966070 | 0.82 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL1969049 | 0.81 | S1PR1 (0.80) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL1964964 | 0.80 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334670-A1 | NEW 2-AMIDOTHIADIAZOLE DERIVATIVES | Almirall S.A. (ES) | 2011-06-22 | — | — | EP | claimed |
| WO-2010043377-A1 | NEW 2-AMIDOTHIADIAZOLE DERIVATIVES | ALMIRALL, S.A. (ES) | 2010-04-22 | — | — | WO | claimed |