Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760032 | 0.84 | COPS5 (0.37) | — | |
| SCHEMBL15652654 | 0.77 | COPS5 (0.44) | MAPT | |
| SCHEMBL15650922 | 0.77 | MAPK1 (0.32) | IKBKETBK1 | |
| SCHEMBL17076691 | 0.75 | HCRTR2 (0.37) | LMNAPOLB | |
| SCHEMBL27571575 | 0.63 | ALDH1A1 (0.37) | MAPT | |
| SCHEMBL15652260 | 0.62 | ALDH1A1 (0.36) | LMNA | |
| SCHEMBL8037695 | 0.62 | ALDH1A1 (0.36) | — | |
| SCHEMBL12292842 | 0.62 | COPS5 (0.44) | POLBMAPT | |
| SCHEMBL10175758 | 0.59 | COPS5 (0.39) | TP53 | |
| SCHEMBL10176188 | 0.59 | CYP1A2 (0.33) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3463359-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | Purdue Pharma LP (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017210616-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | PURDUE PHARMA L.P. (US) | 2017-12-07 | — | — | WO | disclosed |