Sugi Predict

Sugi Predict / Targets / COPS5

COPS5

COP9 signalosome complex subunit 5 · Q92905 · COPS5 on Sugi Atlas →

8,581 patent compounds predicted against COPS5, 5,252 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL353509 SCHEMBL353509 0.58 9/20
SCHEMBL1002345 SCHEMBL1002345 0.54 9/20
SCHEMBL1034370 SCHEMBL1034370 0.54 7/20
SCHEMBL255348 SCHEMBL255348 0.49 6/20
SCHEMBL536578 SCHEMBL536578 1.00 5/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1333579) 0.95 5/20
SCHEMBL1822441 SCHEMBL1822441 0.95 5/20
SCHEMBL688023 SCHEMBL688023 0.61 4/20
SCHEMBL689296 SCHEMBL689296 0.61 4/20
SCHEMBL253871 SCHEMBL253871 0.53 4/20
SCHEMBL687504 SCHEMBL687504 0.52 4/20
SCHEMBL252709 SCHEMBL252709 0.52 4/20
SCHEMBL1096595 SCHEMBL1096595 0.42 4/20
SCHEMBL999293 SCHEMBL999293 0.35 4/20
Alkannin Alkannin (SCHEMBL33968) 1.00 3/20
Shikonin Shikonin (SCHEMBL33969) 1.00 3/20
SCHEMBL1914441 SCHEMBL1914441 0.52 3/20
SCHEMBL371564 SCHEMBL371564 0.52 3/20
SCHEMBL912010 SCHEMBL912010 0.50 3/20
Oxyquinoline Oxyquinoline (SCHEMBL1715327) 0.50 3/20

Clinical trials — most relevant to COPS5 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
A Study to Test How Well BI 3000202 is Tolerated by People With Type 1 Interferonopathies PHASE1ACTIVE_NOT_RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Glutamine Supplementation in People With Immune Dysregulation EARLY_PHASE1WITHDRAWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Implementation of Molecular Diagnostic Pathways nanUNKNOWN
Inherited Reproductive Disorders nanRECRUITING
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Study of Proteus Syndrome and Related Congenital Disorders nanRECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
MEHMO Natural History and Biomarkers nanRECRUITING
Study of Constitutional Platelet Disease nanUNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
The Molecular Basis of Inherited Reproductive Disorders nanACTIVE_NOT_RECRUITING
Gene Analysis of Parkinson's Disease nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD) nanCOMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders nanCOMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
Protein Synthesis in the Brain of Patients With Fragile X Syndrome nanCOMPLETED
The Genetics of Chiari Type I Malformation nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a COPS5 binder may also engage these)

ProteinNameSimilarity
Q6GLM9 — 1.000 Q6GLM9 →
Q6PC30 — 1.000 Q6PC30 →
Q6P635 — 1.000 Q6P635 →
O35864 — 1.000 O35864 →
Q4IJM4 — 1.000 Q4IJM4 →
Q9FVU9 — 1.000 Q9FVU9 →
Q54PF3 — 1.000 Q54PF3 →
P0CQ25 — 1.000 P0CQ25 →
Q9XZ58 — 1.000 Q9XZ58 →
Q8H936 — 1.000 Q8H936 →
PSMD14 26S proteasome non-ATPase regulatory subunit 14 1.000 landscape →
Q7RXX8 — 1.000 Q7RXX8 →
Q6FKS1 — 1.000 Q6FKS1 →
Q9LT08 — 0.999 Q9LT08 →
P0CQ24 — 0.999 P0CQ24 →
P43588 — 0.999 P43588 →
O35593 — 0.998 O35593 →
Q9V3H2 — 0.998 Q9V3H2 →
Q8LAZ7 — 0.998 Q8LAZ7 →
P41878 — 0.998 P41878 →
Q750E9 — 0.997 Q750E9 →
Q4WZP2 — 0.996 Q4WZP2 →
O76577 — 0.996 O76577 →
Q5BBF1 — 0.995 Q5BBF1 →
Q8SQY3 — 0.995 Q8SQY3 →
P91001 — 0.994 P91001 →
Q86IJ1 — 0.993 Q86IJ1 →
Q6C703 — 0.992 Q6C703 →
P41883 — 0.991 P41883 →
Q7SH49 — 0.991 Q7SH49 →