Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | USP8 | P40818 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | USP19 | O94966 | 1/20 | 0.33 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715764 | 0.89 | STAT3 (0.54) | STAT3ALDH1A1MALT1CA1CA2 | |
| SCHEMBL21013876 | 0.82 | STAT3 (0.36) | STAT3ALDH1A1MALT1USP8USP7 | |
| SCHEMBL12640091 | 0.81 | STAT3 (0.43) | STAT3ALDH1A1MALT1CA1CA2 | |
| SCHEMBL29364953 | 0.78 | STAT3 (0.69) | STAT3ALDH1A1MALT1CA1CA2 | |
| SCHEMBL12640078 | 0.78 | ALDH1A1 (0.39) | STAT3ALDH1A1MALT1CA1CA2 | |
| SCHEMBL1881893 | 0.78 | STAT3 (0.69) | STAT3ALDH1A1MALT1CA1CA2 | |
| SCHEMBL45711 | 0.78 | PTGS2 (0.39) | STAT3ALDH1A1MALT1CA1CA2 | |
| SCHEMBL13924800 | 0.78 | STAT3 (0.46) | STAT3ALDH1A1MALT1CA1CA2 | |
| SCHEMBL9328908 | 0.76 | CA1 (0.52) | ALDH1A1MALT1CA1CA2CA7 | |
| SCHEMBL45660 | 0.76 | STAT3 (0.37) | STAT3ALDH1A1MALT1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834532-B2 | Stat3 pathway inhibitors and cancer stem cell inhibitors | BOSTON BIOMEDICAL, INC. (US) | 2017-12-05 | — | — | US | disclosed |