Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19699045 | 1.00 | CA2 (0.41) | CA2CA9PHGDHJAK2JAK1 | |
| SCHEMBL17618814 | 0.91 | HTR2C (0.46) | CA2CA9PHGDHMAPTKDR | |
| SCHEMBL17618431 | 0.91 | CA2 (0.40) | CA2CA9PHGDHKMOMAPT | |
| SCHEMBL17618818 | 0.89 | MPL (0.43) | CA2CA9KMOFYNKDM1A | |
| SCHEMBL17618798 | 0.89 | FYN (0.36) | CA2CA9JAK2KMOMAPT | |
| SCHEMBL17618819 | 0.88 | PHGDH (0.42) | CA2CA9PHGDHKMOMAPT | |
| SCHEMBL17618802 | 0.87 | ALOX15 (0.44) | CA2CA9KMOKDRFGFR1 | |
| SCHEMBL20632458 | 0.87 | PHGDH (0.40) | CA2CA9PHGDHKMOMAPT | |
| SCHEMBL19361167 | 0.87 | PHGDH (0.40) | CA2CA9PHGDHKMOMAPT | |
| SCHEMBL16238547 | 0.87 | PHGDH (0.40) | CA2CA9PHGDHKMOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |