Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618681 | 0.89 | KARS1 (0.35) | KLKB1KLK1KARS1ABL1DYRK1A | |
| SCHEMBL17618689 | 0.89 | KARS1 (0.35) | KLKB1KLK1KARS1ABL1DYRK1A | |
| SCHEMBL17618649 | 0.88 | SCD (0.37) | ACACBJAK2JAK1TYK2MAP3K12 | |
| SCHEMBL17618549 | 0.88 | SCN10A (0.34) | SCN10AJAK2KIF18AABL1 | |
| SCHEMBL17618647 | 0.87 | KARS1 (0.40) | ACACBKARS1MAP3K12 | |
| SCHEMBL19361180 | 0.86 | SCN10A (0.37) | SCN10AKARS1MAP3K12ABL1 | |
| SCHEMBL19670206 | 0.86 | DYRK1A (0.34) | SCN10AKLKB1KLK1KARS1MAP3K12 | |
| SCHEMBL17618520 | 0.85 | USP30 (0.37) | ABL1DYRK1A | |
| SCHEMBL19361179 | 0.85 | CNR2 (0.36) | ACACBKARS1MAP3K12 | |
| SCHEMBL19361177 | 0.81 | MAP3K12 (0.37) | ACACBSCN10AMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |