Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | DLK1 | P80370 | 2/20 | 0.32 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670356 | 0.89 | MAP3K12 (0.34) | DYRK1AGSK3BWNT1MAP3K12DLK1 | |
| SCHEMBL19365545 | 0.88 | TEK (0.32) | DYRK1AGSK3BSCN10ATRPV3 | |
| SCHEMBL19670360 | 0.87 | KARS1 (0.40) | DYRK1AKARS1GSK3BWNT1MAP3K12 | |
| SCHEMBL19669049 | 0.86 | ACACB (0.34) | DYRK1AKARS1KLKB1KLK1MAP3K12 | |
| SCHEMBL19670010 | 0.85 | CLK2 (0.34) | DYRK1AKARS1MAP3K12SCN10ACLK2 | |
| SCHEMBL19365752 | 0.85 | WNT3A (0.37) | DYRK1AGSK3B | |
| SCHEMBL19670226 | 0.85 | CNR2 (0.38) | DYRK1AKARS1GSK3BWNT1MAP3K12 | |
| SCHEMBL19670334 | 0.82 | FGFR4 (0.36) | DYRK1AGSK3BWNT1MAP3K12DLK1 | |
| SCHEMBL19365369 | 0.81 | GSK3B (0.38) | DYRK1AGSK3BCLK2CLK3 | |
| SCHEMBL19670514 | 0.79 | KARS1 (0.34) | DYRK1AKARS1KLKB1KLK1TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |