Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.38 |
| ▸ | PHGDH | O43175 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776220 | 0.91 | PHGDH (0.48) | KMOMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL16775953 | 0.90 | TRPV1 (0.44) | KMOCA2CA9IDH2MEN1 | |
| SCHEMBL16776205 | 0.89 | TSHR (0.46) | KMOCA2CA9IDH2MEN1 | |
| SCHEMBL16775973 | 0.87 | MPL (0.44) | KMOCA2CA9IDH2MEN1 | |
| SCHEMBL17624498 | 0.86 | RHOA (0.40) | KMOCA2CA9IDH2GSK3B | |
| SCHEMBL16238615 | 0.86 | FAAH (0.41) | KMOCA2CA9IDH2MEN1 | |
| SCHEMBL16775962 | 0.86 | CA2 (0.40) | KMOCA2CA9IDH2CCNA2 | |
| SCHEMBL16238412 | 0.85 | PHGDH (0.41) | KMOCA2CA9IDH2MEN1 | |
| SCHEMBL17618905 | 0.85 | PHGDH (0.41) | KMOCA2CA9IDH2MEN1 | |
| SCHEMBL17778806 | 0.85 | MEN1 (0.43) | KMOCA2CA9IDH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |