Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.54 |
| ▸ | NPC1 | O15118 | 10/20 | 0.54 |
| ▸ | RAB9A | P51151 | 10/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21323873 | 0.88 | PDE10A (0.61) | PDE10ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL7457993 | 0.79 | PDE10A (1.00) | PDE10ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL15033460 | 0.79 | PDE10A (0.55) | PDE10ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL21323866 | 0.74 | PDE10A (0.65) | PDE10ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL24113694 | 0.68 | PDE10A (0.61) | PDE10ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL7981713 | 0.67 | PDE10A (0.59) | PDE10ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL2732396 | 0.67 | PDE10A (0.59) | PDE10ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL6847686 | 0.67 | RHOA (0.55) | PDE10ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7834962 | 0.67 | PDE10A (0.59) | PDE10ASMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9971243 | 0.67 | PDE10A (0.59) | PDE10ASMN1; SMN2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834564-B2 | Substituted quinolines as PDE-10 inhibitors | SUNOVION PHARMACEUTICALS INC. (US) | 2017-12-05 | — | — | US | disclosed |