Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510693 | 0.79 | PDE10A (1.00) | PDE10AHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL15023873 | 0.79 | PDE10A (0.55) | PDE10ARAB9ANPC1PAX8CYP2C9 | |
| SCHEMBL15023874 | 0.79 | PDE10A (0.55) | PDE10ARAB9ANPC1PAX8CYP2C9 | |
| SCHEMBL15023872 | 0.79 | PDE10A (0.55) | PDE10ARAB9ANPC1PAX8CYP2C9 | |
| SCHEMBL19669682 | 0.74 | PDE10A (0.65) | PDE10ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6847686 | 0.67 | RHOA (0.55) | PDE10ARAB9ANPC1PAX8CYP2C9 | |
| SCHEMBL16826884 | 0.67 | RAB9A (0.51) | PDE10ARAB9ANPC1PAX8CYP2C9 | |
| SCHEMBL6847690 | 0.67 | RHOA (0.55) | PDE10ARAB9ANPC1PAX8CYP2C9 | |
| SCHEMBL16826886 | 0.67 | RAB9A (0.51) | PDE10ARAB9ANPC1PAX8CYP2C9 | |
| SCHEMBL14736545 | 0.65 | PDE10A (0.56) | PDE10AHDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576540-B1 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2019-09-04 | — | — | EP | disclosed |