Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22366261 | 0.80 | LMNA (0.39) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL6859267 | 0.76 | KDM4E (0.46) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL13588042 | 0.76 | EPHX1 (0.36) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL9171219 | 0.76 | ALDH1A1 (0.36) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL138082 | 0.76 | EPHX1 (0.41) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL29088791 | 0.74 | TDP1 (0.35) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL9242168 | 0.74 | EPHX1 (0.39) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL19669753 | 0.74 | EPHX1 (0.34) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| Dimethylamine SCHEMBL27557791 | 0.72 | EPHX1 (0.38) | LMNAEPHX1KDM4ERAB9ACYP2C9 | |
| SCHEMBL5219501 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |