Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670409 | 0.91 | PRMT5 (0.42) | PRMT5WDR77ATR | |
| SCHEMBL19706071 | 0.89 | MAPK1 (0.33) | PRMT5WDR77HDAC1HDAC2HDAC3 | |
| SCHEMBL19670630 | 0.89 | HDAC1 (0.40) | PRMT5WDR77HDAC1HDAC2HDAC3 | |
| SCHEMBL19365798 | 0.89 | PIK3C3 (0.38) | ATRHDAC1HDAC2HDAC3IGF1R | |
| SCHEMBL19364807 | 0.88 | ATR (0.35) | ATRHDAC1HDAC2HDAC3IGF1R | |
| SCHEMBL19365336 | 0.88 | ATR (0.37) | ATRHDAC1HDAC2HDAC3MAPK1 | |
| SCHEMBL19365606 | 0.88 | ATR (0.48) | ATRHDAC1HDAC2HDAC3IGF1R | |
| SCHEMBL19670256 | 0.88 | FGFR4 (0.36) | PRMT5WDR77HDAC1HDAC2HDAC3 | |
| SCHEMBL19670520 | 0.88 | CPT1A (0.37) | ATRHDAC1HDAC2HDAC3IGF1R | |
| SCHEMBL19670372 | 0.86 | HDAC1 (0.36) | PRMT5WDR77HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |