Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670630 | 0.91 | HDAC1 (0.40) | PRMT5WDR77NPSR1KDM4ELCK | |
| SCHEMBL19669761 | 0.91 | PRMT5 (0.36) | PRMT5WDR77ATR | |
| SCHEMBL19670372 | 0.90 | HDAC1 (0.36) | PRMT5WDR77 | |
| SCHEMBL19365309 | 0.90 | CNR2 (0.40) | GRM5ATRLMNAKDM4E | |
| SCHEMBL19364834 | 0.90 | ALDH1A1 (0.39) | ATR | |
| SCHEMBL19364825 | 0.88 | ATR (0.42) | GRM5ATRKDM4ELCK | |
| SCHEMBL19365441 | 0.88 | ATR (0.48) | TSHRNPSR1KMT2ATDP1ATR | |
| SCHEMBL19365471 | 0.88 | ATR (0.36) | GRM5ATRLMNALCK | |
| SCHEMBL19706240 | 0.88 | WNT1 (0.40) | GRM5KMT2AMEN1ATRLMNA | |
| SCHEMBL19365583 | 0.88 | ABL1 (0.38) | GRM5ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |