Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365305 | 0.92 | ABL1 (0.36) | FGFR4ALOX5APCYP2C9KCNH2HDAC1 | |
| SCHEMBL19365308 | 0.92 | FGFR4 (0.35) | FGFR4ALOX5APCYP2C9KCNH2HDAC1 | |
| SCHEMBL19365791 | 0.91 | FGFR4 (0.34) | FGFR4ALOX5APCYP2C9KCNH2HDAC1 | |
| SCHEMBL19365450 | 0.90 | HDAC1 (0.41) | FGFR4ALOX5APCYP2C9KCNH2HDAC1 | |
| SCHEMBL19706071 | 0.90 | MAPK1 (0.33) | HDAC1ABL1TP53MAPK1PRMT5 | |
| SCHEMBL19365497 | 0.89 | ALOX5AP (0.40) | FGFR4ALOX5APCYP2C9KCNH2HDAC1 | |
| SCHEMBL19669761 | 0.88 | PRMT5 (0.36) | HDAC1ABL1MAPK1PRMT5WDR77 | |
| SCHEMBL19670519 | 0.86 | MAP4K1 (0.41) | ABL1MAP4K1 | |
| SCHEMBL19670409 | 0.85 | PRMT5 (0.42) | TSHRPRMT5WDR77MEN1LMNA | |
| SCHEMBL19670630 | 0.85 | HDAC1 (0.40) | HDAC1ABL1NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |