Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669893 | 0.81 | ALDH1A1 (0.33) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL14079983 | 0.77 | CHRM1 (0.45) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL18133908 | 0.77 | EPHX1 (0.31) | POLBRAB9A | |
| SCHEMBL19104254 | 0.77 | KDM4C (0.31) | POLBRAB9A | |
| SCHEMBL26075251 | 0.73 | CHRM1 (0.42) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL18904831 | 0.72 | CHRM1 (0.45) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL19669889 | 0.72 | KDM4E (0.31) | KDM4EALDH1A1 | |
| SCHEMBL19668991 | 0.72 | CHRM1 (0.43) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL19669892 | 0.69 | TSHR (0.32) | ALDH1A1 | |
| SCHEMBL26073790 | 0.69 | CYP2D6 (0.42) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |