Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.62 |
| ▸ | DHODH | Q02127 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11159408 | 0.89 | MAPT (0.62) | MAPTTRPM8DHODHALDH1A1HSD17B10 | |
| SCHEMBL1968834 | 0.89 | TRPM8 (0.60) | MAPTTRPM8DHODHALDH1A1HSD17B10 | |
| SCHEMBL11161509 | 0.86 | ALDH1A1 (0.76) | MAPTTRPM8DHODHALDH1A1HSD17B10 | |
| SCHEMBL4786383 | 0.86 | DHODH (0.62) | MAPTDHODHALDH1A1HSD17B10HPGD | |
| SCHEMBL1340065 | 0.86 | TRPM8 (0.62) | MAPTTRPM8DHODHALDH1A1HSD17B10 | |
| SCHEMBL6492363 | 0.86 | PTGDR2 (0.55) | MAPTTRPM8DHODHALDH1A1PTGDR2 | |
| SCHEMBL8823153 | 0.86 | ALDH1A1 (0.75) | TRPM8DHODHALDH1A1HSD17B10HPGD | |
| SCHEMBL1968418 | 0.84 | TRPM8 (0.65) | MAPTTRPM8DHODHALDH1A1HSD17B10 | |
| SCHEMBL1968897 | 0.83 | MEN1 (0.65) | MAPTTRPM8DHODHALDH1A1HSD17B10 | |
| SCHEMBL1398715 | 0.81 | PTGDR2 (0.62) | MAPTDHODHALDH1A1PTGDR2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | MAPT 1419/4885TRPM8 161/4885DHODH 3582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.