Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 13/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365473 | 0.88 | FGFR4 (0.39) | PRMT5WDR77FGFR4SIRT2CNR2 | |
| SCHEMBL19670156 | 0.87 | PRMT5 (0.40) | PRMT5WDR77CARM1SIRT2CYP1A2 | |
| SCHEMBL20632604 | 0.84 | FGFR4 (0.45) | FGFR4SIRT2CNR2 | |
| SCHEMBL19670518 | 0.83 | CNR2 (0.52) | FGFR4SIRT2CNR2ALDH1A1 | |
| SCHEMBL19365868 | 0.81 | GPR52 (0.38) | PRMT5WDR77FGFR4 | |
| SCHEMBL19365508 | 0.81 | FGFR4 (0.42) | FGFR4CNR2CYP1A2MAPK1ALDH1A1 | |
| SCHEMBL19865037 | 0.80 | GRM5 (0.36) | CNR2 | |
| SCHEMBL16238378 | 0.80 | PRMT5 (0.41) | PRMT5WDR77CARM1SIRT2 | |
| SCHEMBL16238381 | 0.80 | PRMT5 (0.41) | PRMT5WDR77CARM1SIRT2 | |
| SCHEMBL16238383 | 0.80 | PRMT5 (0.41) | PRMT5WDR77CARM1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |