Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 12/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365513 | 0.91 | PRMT5 (0.41) | PRMT5WDR77CARM1DGAT2SIRT2 | |
| SCHEMBL19670234 | 0.89 | FGFR4 (0.35) | PRMT5WDR77CARM1ADRB2ADRB1 | |
| SCHEMBL19670588 | 0.87 | FGFR4 (0.38) | PRMT5WDR77CARM1ADRB2ADRB1 | |
| SCHEMBL19670160 | 0.87 | PRMT5 (0.42) | PRMT5WDR77CARM1SIRT2CYP1A2 | |
| SCHEMBL19670379 | 0.85 | PRMT5 (0.37) | PRMT5WDR77CARM1DYRK1ACYP1A2 | |
| SCHEMBL19670150 | 0.85 | IRAK4 (0.40) | GSK3BCYP1A2 | |
| SCHEMBL16238378 | 0.85 | PRMT5 (0.41) | PRMT5WDR77CARM1SIRT2ADRB2 | |
| SCHEMBL16238381 | 0.85 | PRMT5 (0.41) | PRMT5WDR77CARM1SIRT2ADRB2 | |
| SCHEMBL16238383 | 0.85 | PRMT5 (0.41) | PRMT5WDR77CARM1SIRT2ADRB2 | |
| SCHEMBL19365317 | 0.84 | GSK3B (0.39) | GSK3BDYRK1ASIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |