Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754616 | 1.00 | MAP4K4 (0.43) | MAP4K4TRPV3EIF2AK4SCN10AACACB | |
| SCHEMBL16754409 | 1.00 | MAP4K4 (0.43) | MAP4K4TRPV3EIF2AK4SCN10AACACB | |
| SCHEMBL19365688 | 1.00 | MAP4K4 (0.43) | MAP4K4TRPV3EIF2AK4SCN10AACACB | |
| SCHEMBL19365533 | 0.91 | MAP4K4 (0.42) | MAP4K4TRPV3EIF2AK4SCN10APDE10A | |
| SCHEMBL17778601 | 0.91 | MAP4K4 (0.42) | MAP4K4TRPV3EIF2AK4SCN10APDE10A | |
| SCHEMBL16249990 | 0.91 | MAP4K4 (0.42) | MAP4K4TRPV3EIF2AK4SCN10APDE10A | |
| SCHEMBL19669086 | 0.91 | MAP4K4 (0.42) | MAP4K4TRPV3EIF2AK4SCN10APDE10A | |
| SCHEMBL16754714 | 0.91 | MAP4K4 (0.42) | MAP4K4TRPV3EIF2AK4SCN10APDE10A | |
| SCHEMBL17778529 | 0.89 | DGAT2 (0.41) | MAP4K4TRPV3EIF2AK4PDE10ADGAT2 | |
| SCHEMBL16754489 | 0.89 | DGAT2 (0.41) | MAP4K4TRPV3EIF2AK4PDE10ADGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |