Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670566 | 0.86 | IDH2 (0.35) | CNR2CNR1KDM1AIDH2MEN1 | |
| SCHEMBL19670326 | 0.84 | SCN9A (0.35) | CNR2CNR1IDH2GAANPSR1 | |
| SCHEMBL19670568 | 0.83 | IDH2 (0.38) | CNR2CNR1IDH2KDM4EMAPT | |
| SCHEMBL19670210 | 0.83 | CNR2 (0.36) | CNR2CNR1KDM1AIDH2KDM4E | |
| SCHEMBL19670570 | 0.82 | IDH2 (0.36) | CNR2CNR1IDH2KDM4EMAPT | |
| SCHEMBL19670330 | 0.81 | IDH2 (0.36) | CNR2CNR1IDH2KDM4EMAPT | |
| SCHEMBL17618368 | 0.81 | KDM4E (0.41) | IDH2KDM4ELMNAUSP2ALOX15 | |
| SCHEMBL17618352 | 0.76 | TRPV1 (0.40) | KDM1AKDM4ELMNAUSP2ALOX15 | |
| SCHEMBL20632424 | 0.70 | KDM1A (0.46) | CNR2CNR1KDM1AIDH2KDM4E | |
| SCHEMBL17618904 | 0.70 | KDM4E (0.42) | IDH2KDM4ELMNAUSP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |