Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.33 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670330 | 0.92 | IDH2 (0.36) | IDH2MAPTBTKCNR2CNR1 | |
| SCHEMBL19670570 | 0.86 | IDH2 (0.36) | IDH2MAPTRPS6KB1CNR2CNR1 | |
| SCHEMBL19670326 | 0.86 | SCN9A (0.35) | IDH2CNR2CNR1 | |
| SCHEMBL19670566 | 0.86 | IDH2 (0.35) | IDH2MAPTRPS6KB1CNR2CNR1 | |
| SCHEMBL19670210 | 0.84 | CNR2 (0.36) | IDH2CNR2CNR1KDM4EHPGD | |
| SCHEMBL19670197 | 0.83 | CNR2 (0.35) | IDH2MAPTCNR2CNR1KDM4E | |
| SCHEMBL17618371 | 0.79 | IDH2 (0.42) | IDH2MAPTRPS6KB1AKT1KDM4E | |
| SCHEMBL19706172 | 0.79 | IDH2 (0.40) | IDH2MAPTRPS6KB1AKT1BTK | |
| SCHEMBL17618358 | 0.74 | RPS6KB1 (0.40) | IDH2MAPTRPS6KB1AKT1 | |
| SCHEMBL19365515 | 0.73 | HTR2C (0.47) | IDH2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |