Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | IDH2 | P48735 | 6/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365695 | 0.86 | ABL1 (0.33) | RPS6KB1KIT | |
| SCHEMBL17618373 | 0.85 | FAAH (0.40) | FAAHIDH2MAPK14BRAFKDR | |
| SCHEMBL19365762 | 0.85 | FAAH (0.40) | FAAHIDH2MAPK14BRAFKDR | |
| SCHEMBL19706172 | 0.83 | IDH2 (0.40) | IDH2BTKRPS6KB1KDM4EHPGD | |
| SCHEMBL19706053 | 0.80 | IDH2 (0.39) | IDH2BTKKDM4E | |
| SCHEMBL19670542 | 0.80 | RHOA (0.39) | IDH2MAPK14PHGDH | |
| SCHEMBL17618367 | 0.80 | FAAH (0.41) | FAAHIDH2MAPK14BRAFKDR | |
| SCHEMBL19706218 | 0.80 | FAAH (0.41) | FAAHIDH2MAPK14BRAFKDR | |
| SCHEMBL19706685 | 0.79 | IDH2 (0.41) | IDH2KIT | |
| SCHEMBL16775963 | 0.77 | FAAH (0.42) | FAAHIDH2MAPK14BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |