Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | UBE2M | P61081 | 2/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365667 | 0.93 | RHOA (0.43) | RHOABRAFCREBBPBRD4CCR3 | |
| SCHEMBL19670170 | 0.88 | BRAF (0.40) | RHOABRAFCREBBPBRD4CCR3 | |
| SCHEMBL19670405 | 0.88 | BRAF (0.40) | RHOABRAFCREBBPBRD4CCR3 | |
| SCHEMBL19670429 | 0.88 | BRAF (0.40) | RHOABRAFCREBBPBRD4CCR3 | |
| SCHEMBL19670179 | 0.87 | HTR2C (0.46) | BRAFMEN1KMT2AUBE2MDCUN1D1 | |
| SCHEMBL19865057 | 0.86 | RHOA (0.41) | RHOABRAFCREBBPBRD4CCR3 | |
| SCHEMBL19365614 | 0.86 | RHOA (0.35) | RHOABRAFCREBBPBRD4CCR3 | |
| SCHEMBL19670329 | 0.86 | RHOA (0.39) | RHOABRAFCREBBPBRD4CCR3 | |
| SCHEMBL19670644 | 0.84 | HSD17B10 (0.37) | BRAFFYNMAPTMEN1KMT2A | |
| SCHEMBL16249975 | 0.84 | RHOA (0.48) | RHOABRAFCREBBPBRD4CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |