Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | HTR2A | P28223 | 6/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365254 | 0.90 | HTR2C (0.47) | HTR2CHTR2AHTR2BCYP1A2FAAH | |
| SCHEMBL19670644 | 0.90 | HSD17B10 (0.37) | HTR2CHTR2AHTR2BCYP1A2UBE2M | |
| SCHEMBL19670589 | 0.89 | HTR2C (0.42) | HTR2CHTR2AHTR2BCYP1A2FAAH | |
| SCHEMBL19670135 | 0.87 | MEN1 (0.41) | HTR2CHTR2ACYP1A2UBE2MDCUN1D1 | |
| SCHEMBL19670212 | 0.87 | RHOA (0.45) | UBE2MDCUN1D1TRPV1MEN1KMT2A | |
| SCHEMBL19365498 | 0.87 | HTR2C (0.46) | HTR2CHTR2AHTR2BCYP1A2FAAH | |
| SCHEMBL19670629 | 0.87 | CA2 (0.40) | HTR2CHTR2ACYP1A2UBE2MDCUN1D1 | |
| SCHEMBL19670393 | 0.86 | ABL1 (0.42) | HTR2CHTR2ACACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670388 | 0.86 | CACNA1G (0.46) | HTR2CHTR2ACACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670214 | 0.86 | TRPA1 (0.38) | UBE2MDCUN1D1KITKDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |