Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | WNT3A | P56704 | 3/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | RHOA | P61586 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670170 | 0.88 | BRAF (0.40) | BRAFCREBBPBRD4CCR3WNT1 | |
| SCHEMBL19670429 | 0.88 | BRAF (0.40) | BRAFCREBBPBRD4CCR3WNT1 | |
| SCHEMBL19670212 | 0.88 | RHOA (0.45) | BRAFCREBBPBRD4CCR3GSK3B | |
| SCHEMBL19865050 | 0.86 | HTR2C (0.40) | WNT3A | |
| SCHEMBL17618694 | 0.84 | BRAF (0.41) | BRAFCREBBPBRD4WNT3ACCR3 | |
| SCHEMBL19670540 | 0.83 | DYRK1A (0.36) | BRAFWNT3AWNT1GSK3BDYRK1A | |
| SCHEMBL19670328 | 0.82 | DYRK1A (0.44) | WNT1GSK3BDYRK1A | |
| SCHEMBL19670512 | 0.82 | BTK (0.37) | WNT3ADYRK1A | |
| SCHEMBL19670135 | 0.81 | MEN1 (0.41) | BRAF | |
| SCHEMBL19365667 | 0.80 | RHOA (0.43) | BRAFCREBBPBRD4CCR3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |