Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654197 | 0.87 | GCK (0.46) | MEN1KMT2AMAPTABL1RAB9A | |
| SCHEMBL20733192 | 0.86 | PIK3CA (0.39) | KMT2AALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL12654670 | 0.85 | CNR1 (0.38) | MEN1KMT2AALDH1A1MAPTCNR2 | |
| SCHEMBL17655390 | 0.84 | GRM5 (0.47) | KMT2AALDH1A1MAPTL3MBTL1CNR2 | |
| SCHEMBL12654429 | 0.83 | PHGDH (0.41) | MEN1KMT2AALDH1A1KDM4EABL1 | |
| SCHEMBL17655384 | 0.83 | TP53 (0.40) | MEN1KMT2AMAPTL3MBTL1CNR2 | |
| SCHEMBL12654215 | 0.82 | TP53 (0.42) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL16775905 | 0.82 | KMT2A (0.39) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL12654669 | 0.82 | CNR2 (0.50) | KMT2AALDH1A1KDM4ECNR2SMN1; SMN2 | |
| SCHEMBL17655421 | 0.82 | CFTR (0.42) | MEN1KMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |