Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654215 | 0.92 | TP53 (0.42) | CNR1TP53GAASMN1; SMN2CNR2 | |
| SCHEMBL12654429 | 0.90 | PHGDH (0.41) | CNR1CNR2MEN1KMT2AALDH1A1 | |
| SCHEMBL17655384 | 0.90 | TP53 (0.40) | CNR1TP53GAASMN1; SMN2CNR2 | |
| SCHEMBL17655390 | 0.89 | GRM5 (0.47) | CNR1SMN1; SMN2CNR2KMT2AMAPT | |
| SCHEMBL1815620 | 0.87 | HTR2C (0.49) | TP53GAASMN1; SMN2 | |
| SCHEMBL12654197 | 0.86 | GCK (0.46) | SMN1; SMN2MEN1KMT2AMAPTGRM5 | |
| SCHEMBL19670230 | 0.85 | MEN1 (0.40) | CNR1SMN1; SMN2CNR2MEN1KMT2A | |
| SCHEMBL12654669 | 0.84 | CNR2 (0.50) | CNR1TP53GAASMN1; SMN2CNR2 | |
| SCHEMBL12654526 | 0.83 | MPL (0.42) | CNR1TP53GAASMN1; SMN2CNR2 | |
| SCHEMBL12654432 | 0.82 | FGFR4 (0.43) | CNR2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |