Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654429 | 0.92 | PHGDH (0.41) | GRM5ALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL12654669 | 0.89 | CNR2 (0.50) | GRM5ALDH1A1SMN1; SMN2CNR2KMT2A | |
| SCHEMBL12654670 | 0.89 | CNR1 (0.38) | GRM5MAPTALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL12654197 | 0.86 | GCK (0.46) | GRM5MAPTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL12654215 | 0.86 | TP53 (0.42) | MAPTALDH1A1SMN1; SMN2L3MBTL1CNR2 | |
| SCHEMBL12654526 | 0.86 | MPL (0.42) | GRM5SMN1; SMN2CNR2CNR1 | |
| SCHEMBL17655384 | 0.85 | TP53 (0.40) | GRM5MAPTSMN1; SMN2L3MBTL1CNR2 | |
| SCHEMBL12654432 | 0.85 | FGFR4 (0.43) | GRM5MAPTALDH1A1CNR2KMT2A | |
| SCHEMBL17655454 | 0.85 | GRM5 (0.43) | GRM5MAPTALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL19670230 | 0.84 | MEN1 (0.40) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |