Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19703416 | 0.88 | CNR2 (0.35) | DYRK1ATP53BP1 | |
| SCHEMBL19365385 | 0.88 | CNR2 (0.35) | DYRK1ATP53BP1 | |
| SCHEMBL19706206 | 0.88 | CA9 (0.37) | NEK2EGFRNTRK1MAP4K1MTOR | |
| SCHEMBL19706066 | 0.87 | FAAH (0.35) | NEK2DYRK1A | |
| SCHEMBL19670259 | 0.87 | FAAH (0.35) | NEK2DYRK1A | |
| SCHEMBL19365358 | 0.87 | FAAH (0.35) | EGFRROCK2ROCK1 | |
| SCHEMBL17618392 | 0.87 | NTRK1 (0.39) | NEK2EGFRNTRK1MAP4K1MTOR | |
| SCHEMBL17618381 | 0.87 | CCNE1 (0.37) | NEK2EGFRNTRK1MAP4K1HCRTR1 | |
| SCHEMBL19706067 | 0.87 | NEK2 (0.34) | NEK2EGFRMTORPIK3CADYRK1A | |
| SCHEMBL19365493 | 0.87 | FAAH (0.40) | NEK2EGFRMTORPIK3CADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |