Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 6/20 | 0.36 |
| ▸ | HTR2B | P41595 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624600 | 1.00 | SCN10A (0.41) | SCN10AARTRPV3HTR2CHTR2B | |
| SCHEMBL19670614 | 0.90 | TRPV3 (0.39) | SCN10AARTRPV3MAP4K4 | |
| SCHEMBL17624205 | 0.90 | TRPV3 (0.39) | SCN10AARTRPV3MAP4K4 | |
| SCHEMBL17624478 | 0.89 | TRPV3 (0.40) | SCN10ATRPV3MAP4K4NTRK1 | |
| SCHEMBL19670286 | 0.89 | TRPV3 (0.40) | SCN10ATRPV3MAP4K4NTRK1 | |
| SCHEMBL19364922 | 0.89 | SCN10A (0.41) | SCN10AARTRPV3HTR2CHTR2B | |
| SCHEMBL19669729 | 0.85 | TRPV1 (0.40) | SCN10ATRPV3HTR2CHTR2AMAP4K4 | |
| SCHEMBL17624532 | 0.85 | TRPV1 (0.40) | SCN10ATRPV3HTR2CHTR2AMAP4K4 | |
| SCHEMBL17624599 | 0.85 | TRPV3 (0.40) | SCN10ATRPV3MAP4K4POLBKDM4E | |
| SCHEMBL19670615 | 0.85 | TRPV3 (0.40) | SCN10ATRPV3MAP4K4POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |