Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624205 | 1.00 | TRPV3 (0.39) | TRPV3SCN10APRMT5WDR77AR | |
| SCHEMBL17624478 | 0.91 | TRPV3 (0.40) | TRPV3SCN10AMAP4K4EIF2AK4DGAT2 | |
| SCHEMBL19670286 | 0.91 | TRPV3 (0.40) | TRPV3SCN10AMAP4K4EIF2AK4DGAT2 | |
| SCHEMBL17624600 | 0.90 | SCN10A (0.41) | TRPV3SCN10AARMAP4K4 | |
| SCHEMBL19670307 | 0.90 | SCN10A (0.41) | TRPV3SCN10AARMAP4K4 | |
| SCHEMBL17624527 | 0.88 | TRPV3 (0.40) | TRPV3SCN10APRMT5WDR77AR | |
| SCHEMBL19670191 | 0.88 | TRPV3 (0.40) | TRPV3SCN10APRMT5WDR77AR | |
| SCHEMBL19364858 | 0.88 | TRPV3 (0.40) | TRPV3SCN10APRMT5WDR77AR | |
| SCHEMBL17624470 | 0.87 | SCN10A (0.41) | TRPV3SCN10APRMT5WDR77AR | |
| SCHEMBL19669729 | 0.87 | TRPV1 (0.40) | TRPV3SCN10AMAP4K4EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |