Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.38 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618799 | 0.87 | FAAH (0.39) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL17624236 | 0.86 | FAAH (0.39) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL19706218 | 0.84 | FAAH (0.41) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL17618367 | 0.84 | FAAH (0.41) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL16775963 | 0.84 | FAAH (0.42) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL17618373 | 0.83 | FAAH (0.40) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL19365762 | 0.83 | FAAH (0.40) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL19365642 | 0.82 | FAAH (0.39) | FAAHADORA2ACA2CA9KMO | |
| SCHEMBL19670310 | 0.81 | FAAH (0.38) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL19365332 | 0.80 | KDR (0.40) | KDRMAPK14TNNI3KBRAFFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |