Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 10/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618782 | 0.86 | FAAH (0.39) | FAAHADORA2AGABRA1ADRA2CHTR2A | |
| SCHEMBL17618349 | 0.83 | FAAH (0.40) | FAAHGABRA1ADRA2CHTR2AHTR2C | |
| SCHEMBL16238615 | 0.83 | FAAH (0.41) | FAAHGABRA1ADRA2CHTR2AHTR2C | |
| SCHEMBL20631976 | 0.82 | RHOA (0.37) | ADORA2ACNR1CNR2KMOCA2 | |
| SCHEMBL19670312 | 0.82 | KDR (0.39) | FAAHADORA2AKMOCA2CA9 | |
| SCHEMBL17624231 | 0.82 | FAAH (0.39) | FAAHGABRA1ADRA2CHTR2AHTR2C | |
| SCHEMBL17618362 | 0.82 | FAAH (0.39) | FAAHGABRA1ADRA2CHTR2AHTR2C | |
| SCHEMBL19365520 | 0.82 | FAAH (0.39) | FAAHGABRA1ADRA2CHTR2AHTR2C | |
| SCHEMBL19365840 | 0.81 | FYN (0.37) | ADORA2AHTR2AHTR2CKMOKMT2A | |
| SCHEMBL19706160 | 0.78 | PHGDH (0.38) | ADORA2AHTR2AHTR2CCNR2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |