Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706163 | 0.89 | FGFR4 (0.40) | FGFR4JAK2NTRK1CDK1CCNB2 | |
| SCHEMBL19670596 | 0.89 | FGFR4 (0.40) | FGFR4JAK2NTRK1CDK1CCNB2 | |
| SCHEMBL19670627 | 0.89 | FGFR4 (0.40) | FGFR4JAK2NTRK1CDK1CCNB2 | |
| SCHEMBL19706102 | 0.84 | FGFR4 (0.40) | FGFR4TRPV1FAAH | |
| SCHEMBL19670545 | 0.83 | FGFR4 (0.40) | FGFR4NPC1TRPV1MEN1KMT2A | |
| SCHEMBL19706295 | 0.83 | FGFR4 (0.40) | FGFR4NPC1TRPV1MEN1KMT2A | |
| SCHEMBL16775803 | 0.81 | FGFR4 (0.48) | FGFR4NPC1TRPV1MEN1KMT2A | |
| SCHEMBL20733295 | 0.76 | DGAT2 (0.38) | FGFR4JAK2NTRK1CDK1CCNB2 | |
| SCHEMBL19670591 | 0.75 | FGFR4 (0.42) | FGFR4FAAHADORA2ACHRNA7CHRNA10 | |
| SCHEMBL19706272 | 0.75 | TRPV3 (0.40) | FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |