Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670494 | 0.83 | SMN1; SMN2 (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 | |
| SCHEMBL19365472 | 0.81 | KDM1A (0.43) | CRHR1RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL19365563 | 0.80 | KMT2A (0.37) | RAB9APOLBPTGESIRAK4MEN1 | |
| SCHEMBL17618751 | 0.80 | CRHR1 (0.37) | CRHR1RAB9ASMN1; SMN2POLBPTGES | |
| SCHEMBL17618627 | 0.79 | CRHR1 (0.35) | CRHR1RAB9ASMN1; SMN2POLBPTGES | |
| SCHEMBL19669949 | 0.79 | GRM5 (0.39) | PTGESIRAK4 | |
| SCHEMBL19706123 | 0.76 | ABL1 (0.39) | RAB9ASMN1; SMN2POLBNPC1FFAR2 | |
| SCHEMBL19670327 | 0.74 | PIK3CD (0.36) | CRHR1PTGESPTGS2PIK3CD | |
| SCHEMBL16776275 | 0.71 | PIK3CG (0.36) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 | |
| SCHEMBL17618835 | 0.71 | ABL1 (0.38) | RAB9ASMN1; SMN2POLBNPC1FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |