Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365787 | 0.85 | SCN10A (0.40) | CRHR1PTGS2KDM1ATRPV3CHRNA7 | |
| SCHEMBL19706290 | 0.84 | MAPT (0.39) | PTGS2KDM1ATRPV3 | |
| SCHEMBL19365548 | 0.82 | TRPV3 (0.37) | CRHR1PTGS2KDM1ATRPV3CHRNA7 | |
| SCHEMBL19670562 | 0.82 | ALOX15 (0.39) | PTGS2KDM1ATRPV3CHRNA7CYP2D6 | |
| SCHEMBL19365666 | 0.82 | HTR2C (0.41) | CYP2D6 | |
| SCHEMBL19706123 | 0.81 | ABL1 (0.39) | ABL1 | |
| SCHEMBL19365860 | 0.81 | CHRNA7 (0.36) | KDM1ATRPV3CHRNA7ABL1DYRK1A | |
| SCHEMBL19670548 | 0.81 | TRPM8 (0.38) | PTGS2KDM1ATRPV3CHRNA7ABL1 | |
| SCHEMBL17618841 | 0.81 | PIK3CD (0.35) | PIK3CDCRHR1TRPV3ABL1DYRK1A | |
| SCHEMBL19365405 | 0.80 | GABRA1 (0.39) | PTGS2KDM1ATRPV3CHRNA7CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |