Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | UBE2M | P61081 | 2/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365507 | 0.91 | MAPT (0.37) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL16238347 | 0.84 | MEN1 (0.39) | MEN1KMT2AUBE2MDCUN1D1MAPT | |
| SCHEMBL19365595 | 0.84 | MAPT (0.38) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL19706097 | 0.81 | MEN1 (0.37) | MEN1KMT2AUBE2MDCUN1D1MAPT | |
| SCHEMBL19706091 | 0.79 | ADORA2A (0.32) | — | |
| SCHEMBL16775854 | 0.79 | SLC5A1 (0.37) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL19670644 | 0.78 | HSD17B10 (0.37) | MEN1KMT2AUBE2MDCUN1D1MAPT | |
| SCHEMBL17618702 | 0.77 | MEN1 (0.39) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL19670179 | 0.77 | HTR2C (0.46) | MEN1KMT2AUBE2MDCUN1D1TRPV1 | |
| SCHEMBL19365333 | 0.76 | KDM1A (0.39) | MEN1KMT2AMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |