Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365708 | 0.91 | MAPT (0.41) | MAPTCA2CA9MEN1KMT2A | |
| SCHEMBL19365254 | 0.90 | HTR2C (0.47) | MAPTMEN1KMT2ASMN1; SMN2HTR2C | |
| SCHEMBL19365904 | 0.89 | MAPT (0.43) | MAPTCA2CA9MEN1KMT2A | |
| SCHEMBL19365507 | 0.87 | MAPT (0.37) | MAPTCA2CA9MEN1KMT2A | |
| SCHEMBL19364877 | 0.87 | TRPV3 (0.38) | MAPTSMN1; SMN2JAK2ALDH1A1 | |
| SCHEMBL19670246 | 0.86 | SCN9A (0.39) | MAPTCA2CA9FYNKDM1A | |
| SCHEMBL19365440 | 0.85 | PIM2 (0.35) | MEN1KMT2AHTR2CHTR2AHTR2B | |
| SCHEMBL19365498 | 0.85 | HTR2C (0.46) | MAPTMEN1KMT2ASMN1; SMN2HTR2C | |
| SCHEMBL19365678 | 0.85 | PDE10A (0.34) | MEN1KMT2AHTTHTR2CHTR2A | |
| SCHEMBL19365433 | 0.85 | PDE10A (0.34) | MEN1KMT2AHTTHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |