Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.44 |
| ▸ | GSK3B | P49841 | 17/20 | 0.44 |
| ▸ | WNT1 | P04628 | 16/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670540 | 0.90 | DYRK1A (0.36) | DYRK1AGSK3BWNT1MTORADORA2A | |
| SCHEMBL19670492 | 0.89 | DYRK1A (0.42) | DYRK1AGSK3BWNT1 | |
| SCHEMBL19670431 | 0.88 | WNT1 (0.40) | DYRK1AGSK3BWNT1MTOR | |
| SCHEMBL19865030 | 0.88 | DYRK1A (0.40) | DYRK1AGSK3BWNT1 | |
| SCHEMBL19365270 | 0.87 | WNT3A (0.40) | DYRK1AGSK3BMTOR | |
| SCHEMBL19365276 | 0.85 | WNT3A (0.41) | DYRK1AGSK3BMTOR | |
| SCHEMBL17618869 | 0.85 | DYRK1A (0.42) | DYRK1AGSK3BWNT1 | |
| SCHEMBL17767959 | 0.85 | DYRK1A (0.42) | DYRK1AGSK3BWNT1 | |
| SCHEMBL19365654 | 0.83 | HCRTR1 (0.44) | — | |
| SCHEMBL19670515 | 0.82 | WNT3A (0.35) | GSK3BMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |