Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365791 | 0.90 | FGFR4 (0.34) | KDRMAPK14TNNI3KBRAFFAAH | |
| SCHEMBL19365829 | 0.89 | KDR (0.39) | KDRMAPK14TNNI3KBRAFPIK3CD | |
| SCHEMBL19365311 | 0.89 | CNR2 (0.39) | MCHR1FAAH | |
| SCHEMBL19365705 | 0.88 | MAP4K4 (0.38) | RAB9AMEN1ALDH1A1KMT2AFAAH | |
| SCHEMBL19365374 | 0.87 | MCHR1 (0.41) | ALDH1A1MCHR1FAAH | |
| SCHEMBL19365450 | 0.87 | HDAC1 (0.41) | MEN1KMT2AEGFRFAAH | |
| SCHEMBL19670421 | 0.85 | MPL (0.44) | KDRMAPK14TNNI3KPOLBRAB9A | |
| SCHEMBL19670601 | 0.85 | POLB (0.41) | POLBRAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL19365497 | 0.84 | ALOX5AP (0.40) | RAB9APIK3CAFAAH | |
| SCHEMBL19670248 | 0.84 | ATR (0.41) | PIK3CDFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |