Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670120 | 0.89 | SCN10A (0.43) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL16754556 | 0.88 | RAF1 (0.39) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL17777128 | 0.88 | RAF1 (0.39) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL16754555 | 0.88 | RAF1 (0.39) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL16754554 | 0.88 | RAF1 (0.39) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL17618393 | 0.86 | KMT2A (0.46) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL17624646 | 0.85 | CA2 (0.42) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL17618783 | 0.84 | MEN1 (0.47) | MEN1KMT2AKDM4EUSP2LMNA | |
| SCHEMBL17618902 | 0.84 | CA2 (0.42) | CA2CA9MEN1KMT2AKDM4E | |
| SCHEMBL17618906 | 0.84 | CA2 (0.42) | CA2CA9MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |