Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624646 | 0.90 | CA2 (0.42) | SCN10ACA2CA9MEN1KMT2A | |
| SCHEMBL17618393 | 0.90 | KMT2A (0.46) | SCN10ASORT1CA2CA9MEN1 | |
| SCHEMBL19670454 | 0.89 | CA2 (0.39) | SCN10ACA2CA9MEN1KMT2A | |
| SCHEMBL17618783 | 0.88 | MEN1 (0.47) | MEN1KMT2ALMNAKDM4EUSP2 | |
| SCHEMBL17618367 | 0.88 | FAAH (0.41) | ABL1BCR | |
| SCHEMBL19706218 | 0.88 | FAAH (0.41) | ABL1BCR | |
| SCHEMBL17777128 | 0.88 | RAF1 (0.39) | SCN10ACA2CA9MEN1KMT2A | |
| SCHEMBL16754556 | 0.88 | RAF1 (0.39) | SCN10ACA2CA9MEN1KMT2A | |
| SCHEMBL16754554 | 0.88 | RAF1 (0.39) | SCN10ACA2CA9MEN1KMT2A | |
| SCHEMBL16754555 | 0.88 | RAF1 (0.39) | SCN10ACA2CA9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |